Ashritha Cheeyandira

Project

Isolating the role of enkephalin release in the Ventral Tegmental Area during behavior

The United States has seen a drastic increase in drug overdoses within the past 10 years, due to the widespread availability of synthetic opioids, like fentanyl. It’s known that the mu-opioid receptor (MOR) binds synthetic opioids, but not much is known about the role of endogenous opioids. My mentor’s dissertation project focuses on gaining a better understanding of endogenous opioid, specifically enkephalin, release in the Ventral Tegmental Area (VTA). The VTA plays a large role in MOR mediated reward seeking and motivated behaviors. Not much is known about the source of enkephalin release into the VTA, but we have identified the Lateral Hypothalamus (LH) as a potential source of enkephalin into the VTA. In my project, I will focus on answering the question: During which behaviors are endogenous enkephalin projections from the LH to the VTA activated?

What I learned

I am extremely grateful to work in the Bruchas Lab where I have not only learned technical lab skills, but also developed my professional skills, specifically on my scientific and professional communication. I have also experienced invaluable mentorship, both in roles as the mentee and mentor. This project has helped me understand how I can make a positive impact on my community while also developing my skillset as a researcher.

Advice for future applicants

Be true to yourself! Ask yourself what drove you to your research or leadership opportunity, and describe your unique story in your application. In order to achieve this goal, use your resources. The MGE team is very helpful and are here to support you however they can, so attend information sessions and/or set up one-on-one meetings.

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