Mary Gates Endowment for Students

Jamie Yang

Project

Optogenetic Suppression of Stem Cell-derived Cardiomyocyte Patch Engraftment Arrhythmias

Heart attacks affect millions of people worldwide by causing non-reversible damage to the heart. As a result, post-heart attack patients are much more susceptible to fatal complications such as heart failure. One potential therapy for post-heart attack patients is engrafting induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) patches to remuscularize scar tissue. However, these patches have been found to introduce potentially lethal arrhythmias. In my project, we seek to examine the efficacy of light-elicited currents (optogenetics) in suppressing such arrhythmias through computer simulations. If we establish that such optogenetic suppression is attainable and safe, we will provide a potential solution for experimental scientists to test further in large animals and possibly humans.

What I learned

I have learned how fundamental concepts from my coursework are applied to solve pertinent challenges in modern medicine. Moreover, I gained valuable technical, critical thinking, and communication skills that will facilitate the path toward reaching my long-term goals. Working on a purely computational project has also allowed me to expand my creativity. I have learned to appreciate and grow with the open-ended nature of my research, as one problem may have boundless solutions.

Advice for future applicants

Find something that you are truly passionate about and can connect to your long-term goals. You should know your project inside out, so make sure to reach out to your mentor(s) for advice and insight. Most importantly, believe in yourself!

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